A house mouse can live without food for about 2 to 4 days. However, this depends significantly on their overall health, hydration level, and the environmental conditions in which they find themselves. It is essential to note that although mice can survive a few days without food, they need to consume water daily. Without water, a house mouse's survival time decreases significantly, often to just a day or two. It's frequently water scarcity rather than a lack of food that causes survival problems for mice.